Competitivemineralocorticoid(aldosterone)receptorantagonistthatexhibitsantihypertensiveactivityinvivo.Alsodisplaysantiandrogenactivityandinhibitssteroidhormonebiosynthesis.
SpironolactoneisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 416.57 |
| Formula | C24H32O4S |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 52-01-7 |
| PubChemID | 5833 |
| InChIKey | LXMSZDCAJNLERA-ZHYRCANASA-N |
| Smiles | O=C1CC[C@@]2(C)C(C[C@@H](SC(C)=O)[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.66 | 100 | |
| ethanol | 20.83 | 50 |
Thefollowingdataisbasedontheproductmolecularweight416.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.4mL | 12mL | 24.01mL |
| 5mM | 0.48mL | 2.4mL | 4.8mL |
| 10mM | 0.24mL | 1.2mL | 2.4mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |



