Competitivemineralocorticoid(aldosterone)receptorantagonistthatexhibitsantihypertensiveactivityinvivo.Alsodisplaysantiandrogenactivityandinhibitssteroidhormonebiosynthesis.
SpironolactoneisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 416.57 |
Formula | C24H32O4S |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 52-01-7 |
PubChemID | 5833 |
InChIKey | LXMSZDCAJNLERA-ZHYRCANASA-N |
Smiles | O=C1CC[C@@]2(C)C(C[C@@H](SC(C)=O)[C@]3([H])[C@@]([H])2CC[C@@]4(C)[C@]([H])3CC[C@@]54OC(CC5)=O)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
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Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 41.66 | 100 | |
ethanol | 20.83 | 50 |
Thefollowingdataisbasedontheproductmolecularweight416.57.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.4mL | 12mL | 24.01mL |
5mM | 0.48mL | 2.4mL | 4.8mL |
10mM | 0.24mL | 1.2mL | 2.4mL |
50mM | 0.05mL | 0.24mL | 0.48mL |