Orallyactive,potentinhibitorofphosphodiesterase5(PDE5)(IC50=4nM).Enhancesnitricoxide-dependentrelaxationofhumancorpuscavernosuminvitro.
SoldforresearchpurposesunderagreementfromPfizerInc.
SildenafilcitrateisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 666.7 |
| Formula | C22H30N6O4S.C6H8O7 |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 171599-83-0 |
| PubChemID | 62853 |
| InChIKey | DEIYFTQMQPDXOT-UHFFFAOYSA-N |
| Smiles | O=C(O)C(O)(CC(O)=O)CC(O)=O.CN1CCN(S(C2=CC=C(OCC)C(C(NC4=C3N(C)N=C4CCC)=NC3=O)=C2)(=O)=O)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 66.67 | 100 |
Thefollowingdataisbasedontheproductmolecularweight666.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.5mL | 7.5mL | 15mL |
| 5mM | 0.3mL | 1.5mL | 3mL |
| 10mM | 0.15mL | 0.75mL | 1.5mL |
| 50mM | 0.03mL | 0.15mL | 0.3mL |



