Sec7-specificGEFinhibitorthatdisplaysselectivityforsmallGEFsofthecytohesinfamily(IC50valuesare2.4,5.4,5.4,5.6,5.6,65and>100μMforhCyh4,hCyh1,mCyh3,hCyh3,drosophilasteppke,yGea2-S7andhEFA6-S7respectively).Inhibitsinsulinsignalingviainhibitionofinsulinreceptorsubstrateprotein(IRS)phosphorylation.
| M.Wt | 460.5 |
| Formula | C24H20N4O4S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 853625-60-2 |
| PubChemID | 1029232 |
| InChIKey | QPGYAMIHXLCFTJ-UHFFFAOYSA-N |
| Smiles | O=C(CSC5=CC=CC=C5)NC(C=C4)=CC=C4N1C(C2=CC(OCO3)=C3C=C2)=NC(OC)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 46.05 | 100 | |
| ethanol | 4.61 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight460.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.17mL | 10.86mL | 21.72mL |
| 5mM | 0.43mL | 2.17mL | 4.34mL |
| 10mM | 0.22mL | 1.09mL | 2.17mL |
| 50mM | 0.04mL | 0.22mL | 0.43mL |



