Rev-Erbα/βagonist(EC50=710nM;Kd=800nM).AlterscircADIanlocomotoractivityandcoreclockhypothalamicgeneexpressioninmice.Inducesweightlossindiet-inducedobesemice.Brainpenetrant.
| M.Wt | 437.94 |
| Formula | C20H24ClN3O4S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1379686-30-2 |
| PubChemID | 57394020 |
| InChIKey | MMJJNHOIVCGAAP-UHFFFAOYSA-N |
| Smiles | ClC(C=C1)=CC=C1CN(CC2CCN(C(OCC)=O)C2)CC3=CC=C([N+]([O-])=O)S3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 43.79 | 100 | |
| ethanol | 43.79 | 100 |
Thefollowingdataisbasedontheproductmolecularweight437.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.28mL | 11.42mL | 22.83mL |
| 5mM | 0.46mL | 2.28mL | 4.57mL |
| 10mM | 0.23mL | 1.14mL | 2.28mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |



