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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SR 8278/4463/10/10 mg
产品编号:4463/10
市  场 价:¥3500.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$175.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SR 8278/4463/10/10 mg
商品介绍
Description:Rev-ErbαantagoNIST
ChemicalName:1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylicacidethylester
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Rev-Erbαantagonist;inhibitsRev-Erbαtranscriptionalrepression(EC50=0.47μM).BlocksactivityofRev-ErbαagonistGSK4112(Cat.No.3663)inHEK293cells.Increasesexpressionofglucose-regulatinggenes,G6PaseandPEPCKinHepG2cells.

TechnicalData

M.Wt361.48
FormulaC18H19NO3S2
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber1254944-66-5
PubChemID53393127
InChIKeyUIEBLUZPSFAFOC-UHFFFAOYSA-N
SmilesCCOC(=O)C1CC2=CC=CC=C2CN1C(=O)C1=CC=C(SC)S1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO36.15100
ethanol18.0750

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight361.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.77mL13.83mL27.66mL
5mM0.55mL2.77mL5.53mL
10mM0.28mL1.38mL2.77mL
50mM0.06mL0.28mL0.55mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet