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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SR 2211/4869/10/10 mg
产品编号:4869/10
市  场 价:¥3900.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$195.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SR 2211/4869/10/10 mg
商品介绍
Description:SelectiveRORγinverseagoNIST
ChemicalName:2-Fluoro-4'-[[4-(4-pyridinylmethyl)-1-piperazinyl]methyl]-a,a-bis(trifluoromethyl)-[1,1'-biphenyl]-4-methanol
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectiveinverseagonistofretinoicacidreceptor-relatedorphanreceptorγ(RORγ)(Ki=105nM;IC50~320nM).ExhibitsweakactivityatliverXreceptorα(LXRα);doesnotaffectthetranscriptionalactivityoffarnesoidXreceptors(FXR),andhasnoimpactonthetranscriptionalactivityofRORα.

LicensingInformation

SoldunderlicensefromTheScrippsResearchInstitute.

CompoundLibraries

SR2211isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt527.48
FormulaC26H24F7N3O
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1359164-11-6
PubChemID51035449
InChIKeyKVHKWAZUPPBMLL-UHFFFAOYSA-N
SmilesFC(C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C4)=C4C(C=C3)=CC=C3CN(CC2)CCN2CC1=CC=NC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.HCl26.3750
DMSO52.75100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight527.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.9mL9.48mL18.96mL
5mM0.38mL1.9mL3.79mL
10mM0.19mL0.95mL1.9mL
50mM0.04mL0.19mL0.38mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet