Selectiveinverseagonistofretinoicacidreceptor-relatedorphanreceptorγ(RORγ)(Ki=105nM;IC50~320nM).ExhibitsweakactivityatliverXreceptorα(LXRα);doesnotaffectthetranscriptionalactivityoffarnesoidXreceptors(FXR),andhasnoimpactonthetranscriptionalactivityofRORα.
SoldunderlicensefromTheScrippsResearchInstitute.
SR2211isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 527.48 |
Formula | C26H24F7N3O |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 1359164-11-6 |
PubChemID | 51035449 |
InChIKey | KVHKWAZUPPBMLL-UHFFFAOYSA-N |
Smiles | FC(C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C4)=C4C(C=C3)=CC=C3CN(CC2)CCN2CC1=CC=NC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.HCl | 26.37 | 50 | |
DMSO | 52.75 | 100 |
Thefollowingdataisbasedontheproductmolecularweight527.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.9mL | 9.48mL | 18.96mL |
5mM | 0.38mL | 1.9mL | 3.79mL |
10mM | 0.19mL | 0.95mL | 1.9mL |
50mM | 0.04mL | 0.19mL | 0.38mL |