SelectivePPARγantagonist;antidiabeticandantiobesityagent.Attenuatestroglitazone-inducedPPARγtranscriptionalactivity(IC50=140μM)withoutaffectingligand-stimulatedPPARα,PPARβorFXRtranscriptionalactivity.InhibitsPPARγ-dependentADIpocytedifferentiationandgrowthinvitroandinvivo.Improvesinsulinsensitivityindiabeticob/obmiceandincreasesHDLlevelsinratsinvivo.
M.Wt | 358.65 |
Formula | C11H17ClO7P2 |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 76541-72-5 |
PubChemID | 60910 |
InChIKey | VQHUQHAPWMNBLP-UHFFFAOYSA-N |
Smiles | COP(=O)(OC)OC(C1=CC=C(Cl)C=C1)P(=O)(OC)OC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
water | 35.87 | 100 |
Thefollowingdataisbasedontheproductmolecularweight358.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.79mL | 13.94mL | 27.88mL |
5mM | 0.56mL | 2.79mL | 5.58mL |
10mM | 0.28mL | 1.39mL | 2.79mL |
50mM | 0.06mL | 0.28mL | 0.56mL |