SelectivePPARγantagonist;antidiabeticandantiobesityagent.Attenuatestroglitazone-inducedPPARγtranscriptionalactivity(IC50=140μM)withoutaffectingligand-stimulatedPPARα,PPARβorFXRtranscriptionalactivity.InhibitsPPARγ-dependentADIpocytedifferentiationandgrowthinvitroandinvivo.Improvesinsulinsensitivityindiabeticob/obmiceandincreasesHDLlevelsinratsinvivo.
| M.Wt | 358.65 |
| Formula | C11H17ClO7P2 |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 76541-72-5 |
| PubChemID | 60910 |
| InChIKey | VQHUQHAPWMNBLP-UHFFFAOYSA-N |
| Smiles | COP(=O)(OC)OC(C1=CC=C(Cl)C=C1)P(=O)(OC)OC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| water | 35.87 | 100 |
Thefollowingdataisbasedontheproductmolecularweight358.65.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.79mL | 13.94mL | 27.88mL |
| 5mM | 0.56mL | 2.79mL | 5.58mL |
| 10mM | 0.28mL | 1.39mL | 2.79mL |
| 50mM | 0.06mL | 0.28mL | 0.56mL |



