PregnaneXreceptor(PXR)agonist(EC50valuesare200and700nMforhumanandrabbitPXRrespectively).ActivatesthefarnesoidXreceptor(FXR)atμMconcentrations.DisplayshypocholesterolaemicactivityviaenchanceddegradationofHMG-CoAreductase.
| M.Wt | 504.53 |
| Formula | C24H42O7P2 |
| Storage | Storeat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 126411-39-0 |
| PubChemID | 446313 |
| InChIKey | YQLJDECYQDRSBI-UHFFFAOYSA-N |
| Smiles | OC1=C(C(C)(C)C)C=C(/C=C(P(OCC)(OCC)=O)/P(OCC)(OCC)=O)C=C1C(C)(C)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 50.45 | 100 | |
| ethanol | 50.45 | 100 |
Thefollowingdataisbasedontheproductmolecularweight504.53.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.98mL | 9.91mL | 19.82mL |
| 5mM | 0.4mL | 1.98mL | 3.96mL |
| 10mM | 0.2mL | 0.99mL | 1.98mL |
| 50mM | 0.04mL | 0.2mL | 0.4mL |



