Retinoicacidreceptor-relatedorphanreceptor(ROR)αandγinverseagonist(Kivaluesare172and111nMforRORαandRORγrespectively).DemonstratesnoactivityatRORβorLXR.SuppressesTh17celldifferentiationandcytokineexpressionandreducestheseverityofdiseaseinananimalmodelofmulitplesclerosis.
SoldunderlicensefromTheScrippsResearchInstitute.
M.Wt | 477.4 |
Formula | C15H13F6N3O4S2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1335106-03-0 |
PubChemID | 44241473 |
InChIKey | OZBSSKGBKHOLGA-UHFFFAOYSA-N |
Smiles | CC1=C(S(NC2=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C2)(=O)=O)SC(NC(C)=O)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 47.74 | 100 | |
ethanol | 47.74 | 100 |
Thefollowingdataisbasedontheproductmolecularweight477.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.09mL | 10.47mL | 20.95mL |
5mM | 0.42mL | 2.09mL | 4.19mL |
10mM | 0.21mL | 1.05mL | 2.09mL |
50mM | 0.04mL | 0.21mL | 0.42mL |