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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SR 1001/4868/10/10 mg
产品编号:4868/10
市  场 价:¥3700.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$185.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SR 1001/4868/10/10 mg
商品介绍
Description:RORα/γinverseagoNIST
ChemicalName:N-[4-Methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolylacetamide
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Retinoicacidreceptor-relatedorphanreceptor(ROR)αandγinverseagonist(Kivaluesare172and111nMforRORαandRORγrespectively).DemonstratesnoactivityatRORβorLXR.SuppressesTh17celldifferentiationandcytokineexpressionandreducestheseverityofdiseaseinananimalmodelofmulitplesclerosis.

LicensingInformation

SoldunderlicensefromTheScrippsResearchInstitute.

TechnicalData

M.Wt477.4
FormulaC15H13F6N3O4S2
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber1335106-03-0
PubChemID44241473
InChIKeyOZBSSKGBKHOLGA-UHFFFAOYSA-N
SmilesCC1=C(S(NC2=CC=C(C(O)(C(F)(F)F)C(F)(F)F)C=C2)(=O)=O)SC(NC(C)=O)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO47.74100
ethanol47.74100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight477.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.09mL10.47mL20.95mL
5mM0.42mL2.09mL4.19mL
10mM0.21mL1.05mL2.09mL
50mM0.04mL0.21mL0.42mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet