Tcell-specificRORγ(RORγt)agonist(EC50=800nMinagenereporterassay).InducesIL-17expressionanddecreasesPD-1expressioninTcellsinvitro.
| M.Wt | 397.7 |
| Formula | C16H10ClF6NO2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 303126-97-8 |
| PubChemID | 2323435 |
| InChIKey | IZVBONMVWLTLNT-UHFFFAOYSA-N |
| Smiles | OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(C=C1)NC(C2=C(C=CC=C2)Cl)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 39.77 | 100 | |
| ethanol | 39.77 | 100 |
Thefollowingdataisbasedontheproductmolecularweight397.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.51mL | 12.57mL | 25.14mL |
| 5mM | 0.5mL | 2.51mL | 5.03mL |
| 10mM | 0.25mL | 1.26mL | 2.51mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |



