Tcell-specificRORγ(RORγt)agonist(EC50=800nMinagenereporterassay).InducesIL-17expressionanddecreasesPD-1expressioninTcellsinvitro.
M.Wt | 397.7 |
Formula | C16H10ClF6NO2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 303126-97-8 |
PubChemID | 2323435 |
InChIKey | IZVBONMVWLTLNT-UHFFFAOYSA-N |
Smiles | OC(C(F)(F)F)(C(F)(F)F)C1=CC=C(C=C1)NC(C2=C(C=CC=C2)Cl)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 39.77 | 100 | |
ethanol | 39.77 | 100 |
Thefollowingdataisbasedontheproductmolecularweight397.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.51mL | 12.57mL | 25.14mL |
5mM | 0.5mL | 2.51mL | 5.03mL |
10mM | 0.25mL | 1.26mL | 2.51mL |
50mM | 0.05mL | 0.25mL | 0.5mL |