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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SN-6/2184/50/50 mg
产品编号:2184/50
市  场 价:¥13700.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$685.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SN-6/2184/50/50 mg
商品介绍
Description:SelectiveNa+/Ca2+exchangeinhibitor(reversemode)
ChemicalName:2-[[4-[(4-Nitrophenyl)methoxy]phenyl]methyl]-4-thiazolidinecarboxylicacidethylester
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveNa+/Ca2+-exchange(NCX)inhibitor;displayssomeselectivityforNCX1.IC50valuesare2.9,16and8.6μMforinhibitionofintracellularNa+-dependent45Ca2+uptakebycellsexpressingNCX1,NCX2andNCX3respectively.HassomeaffinityformAChreceptors(IC50=18μM)butminimalactivityagainstNCKX2andvariousreceptorsandionchannels(IC50>30μM).PreferentiallyblocksCa2+influxmodeandismoreselectiveforNCXisoformsthanKB-R7943(Cat.No.1244).Anti-ischemic;potentlyprotectsagainsthypoxia-inducedrenaltubularcelldamage(IC50=0.63μM).

CompoundLibraries

SN-6isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt402.16
FormulaC20H22N2O5S
StorageDesiccateat+4°C
Purity≥99%(HPLC)
CASNumber415697-08-4
PubChemID10222761
InChIKeyZVYIJXLMBWCGHP-UHFFFAOYSA-N
SmilesCCOC(=O)C1CSC(CC2=CC=C(OCC3=CC=C(C=C3)[N+]([O-])=O)C=C2)N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO40.22100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight402.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.49mL12.43mL24.87mL
5mM0.5mL2.49mL4.97mL
10mM0.25mL1.24mL2.49mL
50mM0.05mL0.25mL0.5mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet