ActivemetaboliteofCPT-11(Cat.No.2688)thatinhibitsDNAtopoisomeraseI(IC50valuesare0.74and1.9μMinP388andEhrlichcellsrespectively).InhibitsDNAandRNAsynthesis(IC50valuesare0.077and1.3μMrespectively)butdoesnotaffectproteinsynthesis.Displayspotentantitumoractivityagainstarangeofhumantumorcelllines(IC50valuesare3.3,13,19and22nMforHCT-116,BEL-7402,HL60andHELAcellsrespectively).
SN38isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 392.4 |
Formula | C22H20N2O5 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 86639-52-3 |
PubChemID | 104842 |
InChIKey | FJHBVJOVLFPMQE-QFIPXVFZSA-N |
Smiles | OC1=CC=C(N=C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)C4=C2CC)C2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 39.24 | 100 |
Thefollowingdataisbasedontheproductmolecularweight392.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.55mL | 12.74mL | 25.48mL |
5mM | 0.51mL | 2.55mL | 5.1mL |
10mM | 0.25mL | 1.27mL | 2.55mL |
50mM | 0.05mL | 0.25mL | 0.51mL |