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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SN 38/2684/10/10 mg
产品编号:2684/10
市  场 价:¥2180.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$109.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SN 38/2684/10/10 mg
商品介绍
Description:DNAtopoisomeraseIinhibitor;antitumor
AlternativeNames:7-Ethyl-10-hydroxycamptothecin
ChemicalName:(4S)-4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

ActivemetaboliteofCPT-11(Cat.No.2688)thatinhibitsDNAtopoisomeraseI(IC50valuesare0.74and1.9μMinP388andEhrlichcellsrespectively).InhibitsDNAandRNAsynthesis(IC50valuesare0.077and1.3μMrespectively)butdoesnotaffectproteinsynthesis.Displayspotentantitumoractivityagainstarangeofhumantumorcelllines(IC50valuesare3.3,13,19and22nMforHCT-116,BEL-7402,HL60andHELAcellsrespectively).

CompoundLibraries

SN38isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt392.4
FormulaC22H20N2O5
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber86639-52-3
PubChemID104842
InChIKeyFJHBVJOVLFPMQE-QFIPXVFZSA-N
SmilesOC1=CC=C(N=C(C(N3C4)=CC([C@](CC)(O)C(OC5)=O)=C5C3=O)C4=C2CC)C2=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO39.24100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight392.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.55mL12.74mL25.48mL
5mM0.51mL2.55mL5.1mL
10mM0.25mL1.27mL2.55mL
50mM0.05mL0.25mL0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet