PositiveregulatorofautophagyinamechanismindependentfromthemTORpathway.IncreasesautophagosomesynthesisandenhancesclearanceofmodelautophagysubstratessuchasmutanthuntingtinandA53Tα-synuclein,associatedwithHuntington'sandParkinson'sdiseases,respectively.Promotesreprogrammingoffibroblaststoneuralstem-likecellsincombinationwithotherchemicalreagents.
SMER28isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 264.12 |
Formula | C11H10BrN3 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 307538-42-7 |
PubChemID | 1560402 |
InChIKey | BCPOLXUSCUFDGE-UHFFFAOYSA-N |
Smiles | C=CCNC2=NC=NC1=CC=C(Br)C=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
ethanol(suppliedpre-dissolvedinabsoluteethanol,27µg/ml) | 13.21 | 50 | |
DMSO | 26.41 | 100 |
Thefollowingdataisbasedontheproductmolecularweight264.12.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.79mL | 18.93mL | 37.86mL |
5mM | 0.76mL | 3.79mL | 7.57mL |
10mM | 0.38mL | 1.89mL | 3.79mL |
50mM | 0.08mL | 0.38mL | 0.76mL |