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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SMBA 1/5314/10/10 mg
产品编号:5314/10
市  场 价:¥3700.00
场      地:美国(厂家直采)
产品分类: 生化试剂>其他>其他试剂>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$185.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SMBA 1/5314/10/10 mg
商品介绍
Description:HighaffinityandselectiveactivatorofBax
ChemicalName:2-[(2-Nitro-9H-fluorene-9-ylidene)methyl]phenol
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighaffinityandselectiveactivatorofBax(Ki=43.3nM).BindstotheS184bindingpockettoblockBaxphosphorylation.DoesnotbindtootherBcl-2familymembers,includingBcl-2,BakandBid.FacilitatesBaxinsertionintothemitochondrialmembraneandpromotesBax-dependentcytochromecrelease.InducesapoptosisinlungcancercelllinesexpressinghighlevelsofBaxselectivelyovernormalcellsexpressinglowlevelsofBax.RepressestumorgrowthofA549lungcancerxenograftsinmice.

TechnicalData

M.Wt315.32
FormulaC20H13NO3
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber906440-37-7
PubChemID349156
InChIKeyPEYKRJBXACUOOB-UHFFFAOYSA-N
SmilesOC(C=CC=C4)=C4C=C2C3=C(C=CC([N+]([O-])=O)=C3)C1=CC=CC=C1/2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO31.53100
ethanol3.1510mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight315.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.17mL15.86mL31.71mL
5mM0.63mL3.17mL6.34mL
10mM0.32mL1.59mL3.17mL
50mM0.06mL0.32mL0.63mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet