HighaffinityandselectiveactivatorofBax(Ki=43.3nM).BindstotheS184bindingpockettoblockBaxphosphorylation.DoesnotbindtootherBcl-2familymembers,includingBcl-2,BakandBid.FacilitatesBaxinsertionintothemitochondrialmembraneandpromotesBax-dependentcytochromecrelease.InducesapoptosisinlungcancercelllinesexpressinghighlevelsofBaxselectivelyovernormalcellsexpressinglowlevelsofBax.RepressestumorgrowthofA549lungcancerxenograftsinmice.
M.Wt | 315.32 |
Formula | C20H13NO3 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 906440-37-7 |
PubChemID | 349156 |
InChIKey | PEYKRJBXACUOOB-UHFFFAOYSA-N |
Smiles | OC(C=CC=C4)=C4C=C2C3=C(C=CC([N+]([O-])=O)=C3)C1=CC=CC=C1/2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 31.53 | 100 | |
ethanol | 3.15 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight315.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.17mL | 15.86mL | 31.71mL |
5mM | 0.63mL | 3.17mL | 6.34mL |
10mM | 0.32mL | 1.59mL | 3.17mL |
50mM | 0.06mL | 0.32mL | 0.63mL |