Potentsteroidreceptorcoactivator3(SRC-3)inhibitor.ReducesSRC1,SRC2andSRC3levelsinbreastcancercelllines.Inhibitscellgrowth(IC50=3.4nM),inducesapoptosisandattenuatesmigrationofMDA-MB48breastcancercellsinvitro.InhibitstumorgrowthinaMDA-MB48cellbreastcancermousemodel.Orallyavailable.
M.Wt | 301.78 |
Formula | C15H15N5.HCl |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
PubChemID | 121513909 |
InChIKey | CDYJHORKRVKALB-NWBUNABESA-N |
Smiles | CN1C(N/N=C(C2=CC=CC=N2)C)=NC3=CC=CC=C13.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 6.04 | 20 | |
water | 15.09 | 50 |
Thefollowingdataisbasedontheproductmolecularweight301.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.31mL | 16.57mL | 33.14mL |
5mM | 0.66mL | 3.31mL | 6.63mL |
10mM | 0.33mL | 1.66mL | 3.31mL |
50mM | 0.07mL | 0.33mL | 0.66mL |