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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SCH 529074/4240/50/50 mg
产品编号:4240/50
市  场 价:¥16100.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$805.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SCH 529074/4240/50/50 mg
商品介绍
Description:Restoresmutantp53activity
ChemicalName:N3-[2-[[4-[Bis(4-chlorophenyl)methyl]-1-piperazinyl]methyl]-4-quinazolinyl]-N1,N1-dimethyl-1,3-propanediamine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Restoresmutantp53activity.Bindsp53DNAbindingdomain(Kd=1-2μM)andrestoreswild-typefunctiontomanyoncogenicmutantsbyactingasachaperone.Inhibitsubiquitinationofp53byHDM2.Triggersapoptosisintumorcelllinesandreducestumorgrowthinaxenograftmodel.

TechnicalData

M.Wt563.56
FormulaC31H36Cl2N6
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber922150-11-6
PubChemID12001922
InChIKeyNCAJLQDPTZBGJV-UHFFFAOYSA-N
SmilesCN(C)CCCNC2=NC(CN3CCN(C(C5=CC=C(Cl)C=C5)C4=CC=C(Cl)C=C4)CC3)=NC1=CC=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto100mMinethanolandto10mMinDMSOwithsonication

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight563.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.77mL8.87mL17.74mL
5mM0.35mL1.77mL3.55mL
10mM0.18mL0.89mL1.77mL
50mM0.04mL0.18mL0.35mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet