Restoresmutantp53activity.Bindsp53DNAbindingdomain(Kd=1-2μM)andrestoreswild-typefunctiontomanyoncogenicmutantsbyactingasachaperone.Inhibitsubiquitinationofp53byHDM2.Triggersapoptosisintumorcelllinesandreducestumorgrowthinaxenograftmodel.
M.Wt | 563.56 |
Formula | C31H36Cl2N6 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 922150-11-6 |
PubChemID | 12001922 |
InChIKey | NCAJLQDPTZBGJV-UHFFFAOYSA-N |
Smiles | CN(C)CCCNC2=NC(CN3CCN(C(C5=CC=C(Cl)C=C5)C4=CC=C(Cl)C=C4)CC3)=NC1=CC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto100mMinethanolandto10mMinDMSOwithsonication |
Thefollowingdataisbasedontheproductmolecularweight563.56.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.77mL | 8.87mL | 17.74mL |
5mM | 0.35mL | 1.77mL | 3.55mL |
10mM | 0.18mL | 0.89mL | 1.77mL |
50mM | 0.04mL | 0.18mL | 0.35mL |