PotentMTH1inhibitor(Kd=49nM).InhibitsRas-inducedmalignanttransformationandincreasesα-actinpromoter-drivenCATactivityinRas-transformedcells.HasnoeffectonRas-inducedERKandJNKactivation.InhibitsRas-inducedmembranerufflinginREF-52fibroblastsandblocksanchorage-independentgrowthofRas-transformedtumorcelllines.AlsoinducesDNAdamageinSW480coloncancercells.
SCH51344isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 316.35 |
Formula | C16H20N4O3 |
Storage | Storeat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 171927-40-5 |
PubChemID | 9995890 |
InChIKey | YWEGXZZAORIRQR-UHFFFAOYSA-N |
Smiles | CC1=NN=C(N3)C1=C(NCCOCCO)C2=C3C=CC(OC)=C2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 31.64 | 100 | |
ethanol | 3.16 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight316.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.16mL | 15.81mL | 31.61mL |
5mM | 0.63mL | 3.16mL | 6.32mL |
10mM | 0.32mL | 1.58mL | 3.16mL |
50mM | 0.06mL | 0.32mL | 0.63mL |