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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SCH 51344/5280/10/10 mg
产品编号:5280/10
市  场 价:¥4100.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$205.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SCH 51344/5280/10/10 mg
商品介绍
Description:PotentMTH1inhibitor
ChemicalName:2-[2-[(6-Methoxy-3-methyl-1H-pyrazolo[3,4-b]quinolin-4-yl)amino]ethoxy]ethanol
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentMTH1inhibitor(Kd=49nM).InhibitsRas-inducedmalignanttransformationandincreasesα-actinpromoter-drivenCATactivityinRas-transformedcells.HasnoeffectonRas-inducedERKandJNKactivation.InhibitsRas-inducedmembranerufflinginREF-52fibroblastsandblocksanchorage-independentgrowthofRas-transformedtumorcelllines.AlsoinducesDNAdamageinSW480coloncancercells.

CompoundLibraries

SCH51344isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt316.35
FormulaC16H20N4O3
StorageStoreat-20°C
Purity≥99%(HPLC)
CASNumber171927-40-5
PubChemID9995890
InChIKeyYWEGXZZAORIRQR-UHFFFAOYSA-N
SmilesCC1=NN=C(N3)C1=C(NCCOCCO)C2=C3C=CC(OC)=C2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO31.64100
ethanol3.1610mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight316.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM3.16mL15.81mL31.61mL
5mM0.63mL3.16mL6.32mL
10mM0.32mL1.58mL3.16mL
50mM0.06mL0.32mL0.63mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet