SelectiveadenosineA2Areceptorantagonist;bindstohumanandratA2Areceptorswithhighaffinity(Kivaluesare0.048and0.5nMrespectively).Displays>23000-foldselectivityforhA2AoverhA1invitrowithminimalaffinityforhA2BandhA3receptors(IC50>10μM).BlocksthecytoprotectiveeffectofA2AagonistCGS-21680(Cat.No.1063).
M.Wt | 389.42 |
Formula | C20H19N7O2 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 316173-57-6 |
PubChemID | 10668061 |
InChIKey | AEULVFLPCJOBCE-UHFFFAOYSA-N |
Smiles | COC1=CC=C(CCCN2N=CC3=C2N=C(N)N2N=C(N=C32)C2=CC=CO2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 38.94 | 100 |
Thefollowingdataisbasedontheproductmolecularweight389.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.57mL | 12.84mL | 25.68mL |
5mM | 0.51mL | 2.57mL | 5.14mL |
10mM | 0.26mL | 1.28mL | 2.57mL |
50mM | 0.05mL | 0.26mL | 0.51mL |