Selectiveinhibitoroftransforminggrowthfactor-βreceptorI(ALK5,TGF-βRI)(IC50=14.3nM).InhibitsTGF-β1-inducedsmad2/3nuclearlocalizationandTGF-βRI-inducedmRNAexpressioninkidneycells.Attenuatesbleomycin-inducedpulmonaryfibrosis.
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SB525334isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 343.42 |
Formula | C21H21N5 |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 356559-20-1 |
PubChemID | 9967941 |
InChIKey | DKPQHFZUICCZHF-UHFFFAOYSA-N |
Smiles | CC1=NC(C4=C(NC(C(C)(C)C)=N4)C2=CC=C(N=CC=N3)C3=C2)=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.HCl | 34.34 | 100 | |
DMSO | 34.34 | 100 |
Thefollowingdataisbasedontheproductmolecularweight343.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.91mL | 14.56mL | 29.12mL |
5mM | 0.58mL | 2.91mL | 5.82mL |
10mM | 0.29mL | 1.46mL | 2.91mL |
50mM | 0.06mL | 0.29mL | 0.58mL |