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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SB 525334/3211/10/10 mg
产品编号:3211/10
市  场 价:¥3980.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$199.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SB 525334/3211/10/10 mg
商品介绍
Description:SelectiveinhibitorofTGF-βRI
ChemicalName:6-[2-(1,1-Dimethylethyl)-5-(6-methyl-2-pyridinyl)-1H-imidazol-4-yl]quinoxaline
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Selectiveinhibitoroftransforminggrowthfactor-βreceptorI(ALK5,TGF-βRI)(IC50=14.3nM).InhibitsTGF-β1-inducedsmad2/3nuclearlocalizationandTGF-βRI-inducedmRNAexpressioninkidneycells.Attenuatesbleomycin-inducedpulmonaryfibrosis.

LicensingInformation

SoldwiththepermissionofGlaxoSmithKline

CompoundLibraries

SB525334isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt343.42
FormulaC21H21N5
StorageStoreat-20°C
Purity≥97%(HPLC)
CASNumber356559-20-1
PubChemID9967941
InChIKeyDKPQHFZUICCZHF-UHFFFAOYSA-N
SmilesCC1=NC(C4=C(NC(C(C)(C)C)=N4)C2=CC=C(N=CC=N3)C3=C2)=CC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.HCl34.34100
DMSO34.34100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight343.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.91mL14.56mL29.12mL
5mM0.58mL2.91mL5.82mL
10mM0.29mL1.46mL2.91mL
50mM0.06mL0.29mL0.58mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet