Selectiveinhibitoroftransforminggrowthfactor-βtypeIreceptor(ALK5),ALK4andALK7(IC50valuesare47and129nMforALK5andALK4respectively).SelectivelyinhibitssignalingfromTGF-βandactivin;doesnotinhibitotherALKfamilymembers.
| M.Wt | 335.4 |
| Formula | C20H21N3O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 694433-59-5 |
| PubChemID | 9858940 |
| InChIKey | WGZOTBUYUFBEPZ-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C1=NC(C2=CC(OCO4)=C4C=C2)=C(C3=NC(C)=CC=C3)N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| 1eq.HCl | 33.54 | 100 | |
| DMSO | 33.54 | 100 | |
| ethanol | 8.38 | 25 |
Thefollowingdataisbasedontheproductmolecularweight335.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.98mL | 14.91mL | 29.82mL |
| 5mM | 0.6mL | 2.98mL | 5.96mL |
| 10mM | 0.3mL | 1.49mL | 2.98mL |
| 50mM | 0.06mL | 0.3mL | 0.6mL |



