Potentandselectiveinhibitorofthetransforminggrowthfactor-β(TGF-β)typeIreceptoractivinreceptor-likekinaseALK5(IC50=94nM),anditsrelativesALK4andALK7.SuppressesTGF-β-inducedproliferationofhumanosteosarcomacells.Stimulatesproliferation,differentiationandsheetformationofESC-derivedendothelialcells.InhibitsTGF-β-inducedEMT,migration,invasionandVEGFsecretioninseveralhumancancercelllines.
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
SB431542isalsoofferedaspartoftheTocriscreenPlus,TocriscreenKinaseInhibitorToolboxIandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 384.39 |
Formula | C22H16N4O3 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 301836-41-9 |
PubChemID | 4521392 |
InChIKey | FHYUGAJXYORMHI-UHFFFAOYSA-N |
Smiles | NC(=O)C1=CC=C(C=C1)C1=NC(=C(N1)C1=CC=CC=N1)C1=CC2=C(OCO2)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 38.44 | 100 | |
ethanol | 3.84 | 10 |
Thefollowingdataisbasedontheproductmolecularweight384.39.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.6mL | 13.01mL | 26.02mL |
5mM | 0.52mL | 2.6mL | 5.2mL |
10mM | 0.26mL | 1.3mL | 2.6mL |
50mM | 0.05mL | 0.26mL | 0.52mL |