PotentCXCR2antagonist(IC50=7.7nM).Exhibits285-foldselectivityforCXCR2overCXCR1.Reducesleukocytenumbersinsynovialfluidinacuteandchronicrabbitarthritismodels.Alsoreducessynovialfluideicosanoidandcytokinelevelsinarabbitchronicarthritismodel.InhibitsproliferationofAMLcelllinesinvitro.
M.Wt | 410.66 |
Formula | C13H10Cl3N3O4S |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 276702-15-9 |
PubChemID | 9887803 |
InChIKey | WTLRWOHEKQGKDS-UHFFFAOYSA-N |
Smiles | ClC1=C(S(=O)(N)=O)C(O)=C(NC(NC2=C(Cl)C(Cl)=CC=C2)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 41.07 | 100 |
Thefollowingdataisbasedontheproductmolecularweight410.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.44mL | 12.18mL | 24.35mL |
5mM | 0.49mL | 2.44mL | 4.87mL |
10mM | 0.24mL | 1.22mL | 2.44mL |
50mM | 0.05mL | 0.24mL | 0.49mL |