PotentCXCR2antagonistthatinhibitsCINC-1-mediatedbutnotC5a-mediatedCa2+mobilization(IC50valuesare3.4and6800nMrespectively).InhibitsCINC-inducedchemotaxisandattenuatesneutrophilaccumulationininflammatorylunginjuryinvivo.
SoldforresearchpurposesunderagreementfromGlaxoSmithKline
M.Wt | 357.16 |
Formula | C14H9BrN6O |
Storage | StoreatRT |
Purity | ≥98%(HPLC) |
CASNumber | 211096-49-0 |
PubChemID | 9841667 |
InChIKey | SEDUMQWZEOMXSO-UHFFFAOYSA-N |
Smiles | O=C(NC3=C(Br)C=CC=C3)NC1=CC=C(C#N)C2=C1NN=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 35.72 | 100 | |
ethanol | 3.57 | 10 |
Thefollowingdataisbasedontheproductmolecularweight357.16.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.8mL | 14mL | 28mL |
5mM | 0.56mL | 2.8mL | 5.6mL |
10mM | 0.28mL | 1.4mL | 2.8mL |
50mM | 0.06mL | 0.28mL | 0.56mL |