HighaffinityandselectiveCB1antagonist(Kd=0.89nM).Exhibits100-foldselectivityforCB1overCB2.AttenuatesCB1agonistAM411-inducedlocomotorsuppressionandreducesfoodintakeinvivo,butdoesnotinducesignsofnausea.
M.Wt | 380.66 |
Formula | C17H12Cl3N3O |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 614726-85-1 |
PubChemID | 66844170 |
InChIKey | BBUKVPCUOHFAQN-UHFFFAOYSA-N |
Smiles | CC1=C(C2=CC=C(C=C2)Cl)N(C3=C(C=C(C=C3)Cl)Cl)N=C1C(N)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 7.61 | 20 | |
ethanol | 7.61 | 20 |
Thefollowingdataisbasedontheproductmolecularweight380.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.63mL | 13.14mL | 26.27mL |
5mM | 0.53mL | 2.63mL | 5.25mL |
10mM | 0.26mL | 1.31mL | 2.63mL |
50mM | 0.05mL | 0.26mL | 0.53mL |