Potent,cell-permeableinhibitorofSonichedgehog(Shh)signaling;highaffinityantagoNISTofsmoothenedactivity(KD=1.2nM).InhibitssmoothenedagonisteffectswithanIC50of20nM(inShh-LIGHT2cells).
SANT-1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 373.5 |
| Formula | C23H27N5 |
| Storage | Desiccateat+4°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 304909-07-7 |
| PubChemID | 6878030 |
| InChIKey | FOORCIAZMIWALX-JJIBRWJFSA-N |
| Smiles | CC1=NN(C(C)=C1C=NN1CCN(CC2=CC=CC=C2)CC1)C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 18.68 | 50 | |
| ethanol | 9.34 | 25 |
Thefollowingdataisbasedontheproductmolecularweight373.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.68mL | 13.39mL | 26.77mL |
| 5mM | 0.54mL | 2.68mL | 5.35mL |
| 10mM | 0.27mL | 1.34mL | 2.68mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |



