Potent,cell-permeableinhibitorofSonichedgehog(Shh)signaling;highaffinityantagoNISTofsmoothenedactivity(KD=1.2nM).InhibitssmoothenedagonisteffectswithanIC50of20nM(inShh-LIGHT2cells).
SANT-1isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 373.5 |
Formula | C23H27N5 |
Storage | Desiccateat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 304909-07-7 |
PubChemID | 6878030 |
InChIKey | FOORCIAZMIWALX-JJIBRWJFSA-N |
Smiles | CC1=NN(C(C)=C1C=NN1CCN(CC2=CC=CC=C2)CC1)C1=CC=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 18.68 | 50 | |
ethanol | 9.34 | 25 |
Thefollowingdataisbasedontheproductmolecularweight373.5.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.68mL | 13.39mL | 26.77mL |
5mM | 0.54mL | 2.68mL | 5.35mL |
10mM | 0.27mL | 1.34mL | 2.68mL |
50mM | 0.05mL | 0.27mL | 0.54mL |