PotentHedgehogsignalingactivator(EC50=0.4nM).Orallybioavailableandbrainpenetrant.
| M.Wt | 556.07 |
| Formula | C29H28ClF2N3O2S |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 946002-48-8 |
| PubChemID | 16678532 |
| InChIKey | YVIFQUJDZSAFKG-UHFFFAOYSA-N |
| Smiles | COC1=C(CN([C@@H]2CC[C@@H](NC)CC2)C(C3=C(Cl)C4=C(C(F)=CC=C4F)S3)=O)C=C(C5=CC=NC=C5)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.61 | 100 | |
| ethanol | 11.12 | 20 |
Thefollowingdataisbasedontheproductmolecularweight556.07.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 1.8mL | 8.99mL | 17.98mL |
| 5mM | 0.36mL | 1.8mL | 3.6mL |
| 10mM | 0.18mL | 0.9mL | 1.8mL |
| 50mM | 0.04mL | 0.18mL | 0.36mL |



