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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/SAG/4366/1/1 mg
产品编号:4366/1
市  场 价:¥3100.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$155.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/SAG/4366/1/1 mg
商品介绍
Description:PotentSmoothenedreceptoragoNIST;activatestheHedgehogsignalingpathway
ChemicalName:3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]benzo[b]thiophene-2-carboxamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentSmoothened(Smo)receptoragonist(Kd=59nM);antagonizesCyclopamineactionattheSmoreceptor.PotentlyactivatestheHedgehogsignalingpathwayinShh-light2cells(EC50~3nM).InducespathwayactivationindependentlyofPtchproteins.PutativeinhibitorofacellularcomponentrequiredforHedgehogsignaling.EnhancesneuronaldifferentiationofiPSCsintodopaminergicneurons.

TechnicalData

M.Wt490.06
FormulaC28H28ClN3OS
StorageStoreat-20°C
Purity≥99%(HPLC)
CASNumber912545-86-9
PubChemID5284330
InChIKeyVFSUUTYAEQOIMW-UHFFFAOYSA-N
SmilesClC2=C(C(N([C@H]4CC[C@H](NC)CC4)CC3=CC=CC(C5=CC=NC=C5)=C3)=O)SC1=CC=CC=C12

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.HCl24.550
DMSO49.01100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight490.06.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.04mL10.2mL20.41mL
5mM0.41mL2.04mL4.08mL
10mM0.2mL1.02mL2.04mL
50mM0.04mL0.2mL0.41mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet