Selectiveσ1receptoragonist(IC50=17.4nM).Exhibitsselectivityforσ1overσ2receptors.InhibitsangiotensinII-inducedcardiomyocytehypertrophyinvitroandattenuatesmyocardialhypertrophyinvivo.Enhancesbrainplasticityandsensorimotorfunctioninaratmodelofexperimentalstroke.
SA4503dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 441.43 |
Formula | C23H32N2O2.2HCl |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 165377-44-6 |
PubChemID | 9954941 |
InChIKey | XWOXAKBQEMQMFH-UHFFFAOYSA-N |
Smiles | COC1=C(OC)C=CC(CCN2CCN(CCCC3=CC=CC=C3)CC2)=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 8.83 | 20 | |
water | 44.14 | 100 |
Thefollowingdataisbasedontheproductmolecularweight441.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.27mL | 11.33mL | 22.65mL |
5mM | 0.45mL | 2.27mL | 4.53mL |
10mM | 0.23mL | 1.13mL | 2.27mL |
50mM | 0.05mL | 0.23mL | 0.45mL |