SuppressessuperoxideproductionbycomplexIIIinthemitochondriawithoutaffectingnormalelectronfluxorcellularoxidativephosphorylation(IC50=1.7μM).SuppressesHIF-1αaccumulationandenhancessurvivalandfunctionofprimarypancreaticisletsinvitro.Cellpermeable.
M.Wt | 323.44 |
Formula | C19H25N5 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 890888-12-7 |
PubChemID | 17017624 |
InChIKey | MGIAJZSCNPODRR-UHFFFAOYSA-N |
Smiles | CC(C(C)=C1)=CC=C1N2C3=NC=NC(N(CCC)CCC)=C3C=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 6.47 | 20mMwithgentlewarming | |
ethanol | 6.47 | 20mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight323.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.09mL | 15.46mL | 30.92mL |
5mM | 0.62mL | 3.09mL | 6.18mL |
10mM | 0.31mL | 1.55mL | 3.09mL |
50mM | 0.06mL | 0.31mL | 0.62mL |