Inverseagonistoftheconstitutiveandrostanereceptor(CAR).InhibitsCARactivityviarecruitmentofnuclearreceptorco-repressor(NCoR).SuppressesCITCO-inducedCYP2B6geneexpressioninhumanprimaryhepatocytes.
S07662isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 300.38 |
Formula | C16H16N2O2S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 883226-64-0 |
PubChemID | 2732040 |
InChIKey | UITFWLJMEZPXOF-UHFFFAOYSA-N |
Smiles | CC2=C(CNC(NCC3=CC=CS3)=O)C1=CC=CC=C1O2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 30.04 | 100 | |
ethanol | 15.02 | 50 |
Thefollowingdataisbasedontheproductmolecularweight300.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.33mL | 16.65mL | 33.29mL |
5mM | 0.67mL | 3.33mL | 6.66mL |
10mM | 0.33mL | 1.66mL | 3.33mL |
50mM | 0.07mL | 0.33mL | 0.67mL |