Potentandselectiveirreversiblehumanrhinovirus(HRV)3Cproteaseinhibitor(EC50=5nM).Exhibitsnosignificantinhibitionagainstavarietyofserineandcysteineproteases.Inhibitsreplicationofapanelof48differentHRVSEROtypesinH1-HeLAandMRC-5cellprotectionassays.
SoldforresearchpurposesunderagreementfromPfizerInc.
M.Wt | 598.66 |
Formula | C31H39FN4O7 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 223537-30-2 |
PubChemID | 6440352CAY |
InChIKey | CAYJBRBGZBCZKO-BHGBQCOSSA-N |
Smiles | O=C(C1=NOC(C)=C1)N[C@@H](C(C)C)C(C[C@@H](CC2=CC=C(F)C=C2)C(N[C@H](/C=C/C(OCC)=O)C[C@@H]3CCNC3=O)=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 59.87 | 100 |
Thefollowingdataisbasedontheproductmolecularweight598.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.67mL | 8.35mL | 16.7mL |
5mM | 0.33mL | 1.67mL | 3.34mL |
10mM | 0.17mL | 0.84mL | 1.67mL |
50mM | 0.03mL | 0.17mL | 0.33mL |