Potentandcompetitivekynurenine3-monooxygenase(kynurenine3-hydroxylase;KMO)inhibitor(Ki=4.8nM,IC50=37nM).IncreaseskynurenicacidlevelstoconcentrationsthatantagonizetheglycinesiteofNMDAreceptors.Brainpenetrantandexhibitsantidystonic,anticonvulsantandneuroprotectiveactivities.
Ro61-8048isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 421.45 |
Formula | C17H15N3O6S2 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 199666-03-0 |
PubChemID | 5282337 |
InChIKey | NDPBMCKQJOZAQX-UHFFFAOYSA-N |
Smiles | O=S(NC1=NC(C2=CC=CC([N+]([O-])=O)=C2)=CS1)(C3=CC=C(OC)C(OC)=C3)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 42.15 | 100 | |
ethanol | 4.21 | 10 |
Thefollowingdataisbasedontheproductmolecularweight421.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.37mL | 11.86mL | 23.73mL |
5mM | 0.47mL | 2.37mL | 4.75mL |
10mM | 0.24mL | 1.19mL | 2.37mL |
50mM | 0.05mL | 0.24mL | 0.47mL |