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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Ro 61-8048/3254/50/50 mg
产品编号:3254/50
市  场 价:¥14100.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$705.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Ro 61-8048/3254/50/50 mg
商品介绍
Description:Potentkynurenine3-monooxygenase(KMO)inhibitor
ChemicalName:3,4-Dimethoxy-N-[4-(3-nitrophenyl)-2-thiazolyl]benzenesulfonamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandcompetitivekynurenine3-monooxygenase(kynurenine3-hydroxylase;KMO)inhibitor(Ki=4.8nM,IC50=37nM).IncreaseskynurenicacidlevelstoconcentrationsthatantagonizetheglycinesiteofNMDAreceptors.Brainpenetrantandexhibitsantidystonic,anticonvulsantandneuroprotectiveactivities.

CompoundLibraries

Ro61-8048isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt421.45
FormulaC17H15N3O6S2
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber199666-03-0
PubChemID5282337
InChIKeyNDPBMCKQJOZAQX-UHFFFAOYSA-N
SmilesO=S(NC1=NC(C2=CC=CC([N+]([O-])=O)=C2)=CS1)(C3=CC=C(OC)C(OC)=C3)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO42.15100
ethanol4.2110

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight421.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.37mL11.86mL23.73mL
5mM0.47mL2.37mL4.75mL
10mM0.24mL1.19mL2.37mL
50mM0.05mL0.24mL0.47mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet