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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Ro 48-8071 fumarate/5389/50/50 mg
产品编号:5389/50
市  场 价:¥7180.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$359.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Ro 48-8071 fumarate/5389/50/50 mg
商品介绍
Description:2,3-Oxidosqualenecyclase(OSC)inhibitor;blockscholesterolsynthesis
ChemicalName:(4-Bromophenyl)[2-fluoro-4-[[6-(methyl-2-propen-1-ylamino)hexyl]oxy]phenyl]methanone
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

2,3-Oxidosqualenecyclase(OSC)inhibitor(IC50=6.5nM);blockscholesterolsynthesisinHepG2cells.ReducesviABIlityofbreastcancercelllines.AlsoinhibitsEbolavirus(EBOV)cellentry(IC50=1.74μM).

CompoundLibraries

Ro48-8071fumarateisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt564.44
FormulaC23H27BrFNO2.C4H4O4
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber189197-69-1
PubChemID9959583
InChIKeyXCYAYLWZCRGKDS-WLHGVMLRSA-N
SmilesFC1=C(C(C2=CC=C(Br)C=C2)=O)C=CC(OCCCCCCN(C)CC=C)=C1.OC(/C=C/C(O)=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO56.44100
water11.2920mMwithgentlewarming

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight564.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.77mL8.86mL17.72mL
5mM0.35mL1.77mL3.54mL
10mM0.18mL0.89mL1.77mL
50mM0.04mL0.18mL0.35mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet