Potent,collagenase-selectiveMMPinhibitor(Kivaluesare3.0,3.4,4.4,59,154and527nMforMMP-1,MMP-13,MMP-8,MMP-9,MMP-2andMMP-3respectively).Inhibitscartilagebreakdowninvitroandinvivoanddisplaysantiarthriticactivity.Orallyactive.
M.Wt | 436.55 |
Formula | C22H36N4O5 |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
CASNumber | 190648-49-8 |
PubChemID | 9824350 |
InChIKey | GFUITADOEPNRML-SJORKVTESA-N |
Smiles | O=[C@@](N3CCCCC3)[C@H](CC1CCCC1)[C@@H]([C@](NO)=O)CN2C(N(C)C(C)(C)C2=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 43.66 | 100 | |
ethanol | 43.66 | 100 |
Thefollowingdataisbasedontheproductmolecularweight436.55.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.29mL | 11.45mL | 22.91mL |
5mM | 0.46mL | 2.29mL | 4.58mL |
10mM | 0.23mL | 1.15mL | 2.29mL |
50mM | 0.05mL | 0.23mL | 0.46mL |