Non-peptideinhibitorofNGFthatbindstheNGFdimer(KD~1μM)possIBLycausingaconformationalchange.SelectivelyinhibitsbindingofNGFtop75NTRatsubmicromolarconcentrations,andtobothp75NTRandTrkAatconcentrations>5μM.PreventsNGF-inducedapoptosisinSK-N-MCcells.
M.Wt | 270.24 |
Formula | C13H10N4O3 |
Storage | Storeat-20°C |
Purity | ≥95%(HPLC) |
CASNumber | 37854-59-4 |
PubChemID | 17756791 |
InChIKey | JDEMVNYMYPJJIM-UHFFFAOYSA-N |
Smiles | CN1C2=CC(C=O)=C(C)C=C2N=C2C(=O)NC(=O)N=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.NaOH | 13.51 | 50 | |
DMSO | 2.7 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight270.24.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.7mL | 18.5mL | 37mL |
5mM | 0.74mL | 3.7mL | 7.4mL |
10mM | 0.37mL | 1.85mL | 3.7mL |
50mM | 0.07mL | 0.37mL | 0.74mL |