HIV-1andHIV-2proteaseinhibitor(EC50valuesare0.022-0.13and0.16μM,respectively).BlocksthemetabolismofproteaseinhibitorsbyliverenzymecytochromeP450-3A4(CYP3A4).Orallybioavailable.
M.Wt | 720.94 |
Formula | C37H48N6O5S2 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 155213-67-5 |
PubChemID | 392622 |
InChIKey | NCDNCNXCDXHOMX-XGKFQTDJSA-N |
Smiles | O[C@@H](C[C@@H](NC([C@H](C(C)C)NC(N(C)CC1=CSC(C(C)C)=N1)=O)=O)CC2=CC=CC=C2)[C@@H](NC(OCC3=CN=CS3)=O)CC4=CC=CC=C4 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 14.42 | 20mMwithgentlewarming | |
ethanol | 7.21 | 10 |
Thefollowingdataisbasedontheproductmolecularweight720.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 1.39mL | 6.94mL | 13.87mL |
5mM | 0.28mL | 1.39mL | 2.77mL |
10mM | 0.14mL | 0.69mL | 1.39mL |
50mM | 0.03mL | 0.14mL | 0.28mL |