Description:PregnaneXreceptorago
NIST;antibiotic
ChemicalName:(2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences
BiologicalActivity
PregnaneXreceptor(PXR)agonist;antibiotic.ReducesnumberofcolontumorsandsuppressesexpressionofTNFαandIl-1βinducedinacoloncancer,PXR-humanizedmousemodel.IncreasesapoptosisanddecreasedproliferationinHT-29cells.Exhibitslowgastrointestinalabsorptionwhileretainingitsantibacterialactivity.Activeagainstgram-positiveandgram-negativebacteria.
TechnicalData
M.Wt | 785.88 |
Formula | C43H51N3O11 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 80621-81-4 |
PubChemID | 6436173 |
InChIKey | NZCRJKRKKOLAOJ-XRCRFVBUSA-N |
Smiles | O=C(/C(C)=CC=C[C@H](C)[C@H](O)[C@H]([C@H]([C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@@]5(C)O4)O)C)NC2=C(O)C1=C(O)C(C)=C4C(C5=O)=C1C3=C2N6C(C=C(C)C=C6)=N3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
SolubilityData
| Solvent | MaxConc.mg/mL | MaxConc.mM |
---|
Solubility |
---|
DMSO | 78.59 | 100 |
ethanol | 78.59 | 100 |
PreparingStockSolutions
Thefollowingdataisbasedontheproductmolecularweight785.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|
1mM | 1.27mL | 6.36mL | 12.72mL |
5mM | 0.25mL | 1.27mL | 2.54mL |
10mM | 0.13mL | 0.64mL | 1.27mL |
50mM | 0.03mL | 0.13mL | 0.25mL |
ProductDatasheets
CertificateofAnalysis/ProductDatasheet
SafetyDatasheet
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