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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Ribavirin/4501/50/50 mg
产品编号:4501/50
市  场 价:¥2180.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$109.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Ribavirin/4501/50/50 mg
商品介绍
Description:Antiviralguanosineanalog;blockseIF4Eactivity
ChemicalName:1-β-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Antiviralguanosineribonucleosideanalog;misincorporatedintomRNAbyviral-dependentRNApolymerases.BindstoandredistributesmammalianeIF4Efromthenucleustothecytoplasm(Ki~0.3μMfortheactivemetabolite,ribavirintriphosphate).RepressescolonyformationofprimaryAML-M5Progenitorcells(IC50~1μM);reducesdiseaseseverityinacutemyeloidleukemia(AML).Orallyavailable.

CompoundLibraries

RibavirinisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt244.2
FormulaC8H12N4O5
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber36791-04-5
PubChemID37542
InChIKeyIWUCXVSUMQZMFG-AFCXAGJDSA-N
SmilesO[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(C(N)=O)=N2)[C@@H]1O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO24.42100
water24.42100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight244.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.1mL20.48mL40.95mL
5mM0.82mL4.1mL8.19mL
10mM0.41mL2.05mL4.1mL
50mM0.08mL0.41mL0.82mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet