Antiviralguanosineribonucleosideanalog;misincorporatedintomRNAbyviral-dependentRNApolymerases.BindstoandredistributesmammalianeIF4Efromthenucleustothecytoplasm(Ki~0.3μMfortheactivemetabolite,ribavirintriphosphate).RepressescolonyformationofprimaryAML-M5Progenitorcells(IC50~1μM);reducesdiseaseseverityinacutemyeloidleukemia(AML).Orallyavailable.
RibavirinisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 244.2 |
Formula | C8H12N4O5 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 36791-04-5 |
PubChemID | 37542 |
InChIKey | IWUCXVSUMQZMFG-AFCXAGJDSA-N |
Smiles | O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(C(N)=O)=N2)[C@@H]1O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 24.42 | 100 | |
water | 24.42 | 100 |
Thefollowingdataisbasedontheproductmolecularweight244.2.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.1mL | 20.48mL | 40.95mL |
5mM | 0.82mL | 4.1mL | 8.19mL |
10mM | 0.41mL | 2.05mL | 4.1mL |
50mM | 0.08mL | 0.41mL | 0.82mL |