Toll-likereceptor7(TLR7)agonist.InducesupregulationofIL-6,IL-12,IFN-γandiNOSexpressioninmousebonemarrow-derivedmacrophages(BMMs).InhibitsRANKL-inducedosteoclastdifferentiationinmouseBMMsandhumanperipheralbloodmonocytes.AlsopromotesthedifferentiationofMDSCsintomacrophagesanddendriticcells.Proinflammatoryandantiviral.
ResiquimodisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 314.38 |
Formula | C17H22N4O2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 144875-48-9 |
PubChemID | 159603 |
InChIKey | BXNMTOQRYBFHNZ-UHFFFAOYSA-N |
Smiles | NC1=C3C(N(CC(C)(O)C)C(COCC)=N3)=C2C(C=CC=C2)=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 31.44 | 100 | |
ethanol | 15.72 | 50 |
Thefollowingdataisbasedontheproductmolecularweight314.38.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.18mL | 15.9mL | 31.81mL |
5mM | 0.64mL | 3.18mL | 6.36mL |
10mM | 0.32mL | 1.59mL | 3.18mL |
50mM | 0.06mL | 0.32mL | 0.64mL |