PotentandselectiveinhibitoroftheTGF-βtypeIreceptor/ALK5(IC50valuesare4and23nMforTGF-βtypeIreceptorautophosphorylationandbindingrespectively).SelectiveforTGF-βtypeIreceptoroverarangeofkinases,includingp38MAPK,JNK1andGSK3(IC50>16μM).Enhancestheefficiencyofcellularreprogramming;replacesSox2byinducingNanogexpression.
RepSoxisalsoofferedaspartoftheTocriscreenPlusandTocriscreenStemCellToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 287.32 |
Formula | C17H13N5 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 446859-33-2 |
PubChemID | 449054 |
InChIKey | LBPKYPYHDKKRFS-UHFFFAOYSA-N |
Smiles | CC1=NC(C2=NNC=C2C4=NC3=CC=CN=C3C=C4)=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 28.73 | 100 | |
ethanol | 14.37 | 50 |
Thefollowingdataisbasedontheproductmolecularweight287.32.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 3.48mL | 17.4mL | 34.8mL |
5mM | 0.7mL | 3.48mL | 6.96mL |
10mM | 0.35mL | 1.74mL | 3.48mL |
50mM | 0.07mL | 0.35mL | 0.7mL |