Antianginalagentwithantiarrhythmicpropertiesthatactsasapartialfattyacidoxidationinhibitor.Activatespyruvatedehydrogenaseinischemicmyocytestopromoteglucoseoxidation,switchingsubstrateutilizationfromfattyacidstoglucose.AlsoshowntoinhibitlateINaandIKrcurrents.
RanolazinedihydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 500.46 |
Formula | C24H33N3O4.2HCl |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 95635-56-6 |
PubChemID | 71279 |
InChIKey | RJNSNFZXAZXOFX-UHFFFAOYSA-N |
Smiles | COC1=CC=CC=C1OCC(CN2CCN(CC(NC3=C(C)C=CC=C3C)=O)CC2)O.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 50.05 | 100 | |
water | 50.05 | 100 |
Thefollowingdataisbasedontheproductmolecularweight500.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2mL | 9.99mL | 19.98mL |
5mM | 0.4mL | 2mL | 4mL |
10mM | 0.2mL | 1mL | 2mL |
50mM | 0.04mL | 0.2mL | 0.4mL |