Antifungalantibiotic.Inhibitsheatshockprotein90(Hsp90)activitybybindingtotheATP-bindingpocket,subsequentlysuppressingcelltransformationinducedbysrc,rasandmos.Repressesestrogenreceptortranscriptionalactivityandinhibitsangiogenesis.
| M.Wt | 364.78 |
| Formula | C18H17ClO6 |
| Storage | Desiccateat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 12772-57-5 |
| PubChemID | 6323491 |
| InChIKey | WYZWZEOGROVVHK-GTMNPGAYSA-N |
| Smiles | O=C2/C=C/C=C[C@@H](O3)[C@H]3C[C@@H](C)OC(C1=C(O)C=C(O)C(Cl)=C1C2)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| ethanol | 9.12 | 25 |
Thefollowingdataisbasedontheproductmolecularweight364.78.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.74mL | 13.71mL | 27.41mL |
| 5mM | 0.55mL | 2.74mL | 5.48mL |
| 10mM | 0.27mL | 1.37mL | 2.74mL |
| 50mM | 0.05mL | 0.27mL | 0.55mL |



