Hedgehogacyltransferase(Hhat)inhibitor(IC50=850nM).InhibitsSonicHedgehogN(ShhN)palmitoylationinvitro.Hasnoeffectonporcupine-inducedfattyacidacylationofWnt39a.Attenuatespancreaticcancercellproliferation.Cellpermeable.
RU-SKI43hydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 423.01 |
Formula | C22H30N2O2S.HCl |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
PubChemID | 90488982 |
InChIKey | JBBKLHJLHRGJSQ-UHFFFAOYSA-N |
Smiles | O=C(CNCC(CC)C)N1CCC3=C(C=CS3)C1COC2=CC(C)=CC=C2.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 42.3 | 100 |
Thefollowingdataisbasedontheproductmolecularweight423.01.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.36mL | 11.82mL | 23.64mL |
5mM | 0.47mL | 2.36mL | 4.73mL |
10mM | 0.24mL | 1.18mL | 2.36mL |
50mM | 0.05mL | 0.24mL | 0.47mL |