Potentandselectiveantagonistforthemineralocorticoidreceptor(MR).Inhibitsaldosteroneproductionandsecretion,andselectivelydecreasesex-vivoMRbindinginthehippocampusofadrenalectomisedrats.Alsodecreasesbloodpressureinfemaleratsfollowingcentraladministrationinvivo.
M.Wt | 440.66 |
Formula | C25H37O4K |
Storage | Desiccateat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 76676-34-1 |
PubChemID | 23677972 |
InChIKey | HXJITUGMCJCKCE-UYOQDFFISA-M |
Smiles | [K+].[H][C@@]12CC[C@@](O)(CCC([O-])=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])[C@H](CCC)CC2=CC(=O)CC[C@]12C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 4.41 | 10 | |
ethanol | 44.07 | 100 | |
water | 44.07 | 100 |
Thefollowingdataisbasedontheproductmolecularweight440.66.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.27mL | 11.35mL | 22.69mL |
5mM | 0.45mL | 2.27mL | 4.54mL |
10mM | 0.23mL | 1.13mL | 2.27mL |
50mM | 0.05mL | 0.23mL | 0.45mL |