CCR2-selective chemokine receptor antagonist (IC50 values are 0.36 and 17.8 μM for inhibition of human recombinant CCR2b and CCR1 receptors respectively). Blocks MCP-1-stimulated calcium influx and chemotaxis with IC50 values of 32 nM and 1.7 μM respectively. Also inhibits α1A, α1D and 5-HT1A receptors.
RS 102895 hydrochloride is also offered as part of the Tocriscreen Plus. Find out more about compound libraries available from Tocris.
M. Wt | 426.86 |
Formula | C21H21F3N2O2.HCl |
Storage | Desiccate at RT |
Purity | ≥99% (HPLC) |
CAS Number | 1173022-16-6 |
PubChem ID | 16759153 |
InChI Key | KRRISOFSWVKYBF-UHFFFAOYSA-N |
Smiles | Cl.FC(F)(F)C1=CC=C(CCN2CCC3(CC2)OC(=O)NC2=CC=CC=C32)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
DMSO | 32.01 | 75 |
The following data is based on the product molecular weight 426.86. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 2.34 mL | 11.71 mL | 23.43 mL |
5 mM | 0.47 mL | 2.34 mL | 4.69 mL |
10 mM | 0.23 mL | 1.17 mL | 2.34 mL |
50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
References are publications that support the products' biological activity.
Clark et al (1983) Synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'piperidin]-2(1H)-ones. J.Med.Chem. 26 657 PMID: 6842505
Mirzadegan et al (2000) Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists. J.Biol.Chem. 275 25562 PMID: 10770925
Keywords: RS 102895 hydrochloride, supplier, CCR2b, chemokine, receptor, antagonists, Chemokine, Receptors, RS102895, hydrochloride, Chemokine, CC, Receptors, Chemokine, CC, Receptors, Tocris Bioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌,其产品也广为各大药厂、大学、研究机构,超过五万名科学研究者所采用。 目前,產品內容已超過一千六百種以上,並每年持續不斷的增加新的產品。目前,产品内容已超过一千六百种以上,并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔(Bristol)的高品质试剂提供商,共有2000多种产品,主要集中在神经科学和信号传导领域,产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等,主要产品包括GPCR ligands,神经传递素,离子通道调控剂,信号通路抑制剂等,这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者,其生产的影响神经系统的化学物质被多次引用,这些物质很多都来自Jeff Watkins(Tocris 的创立人)在Bristol大学原创性的研究工作。
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