Potentlysinespecificdemethylase1(LSD1)inhibitor(IC50=70nM).ExhibitsselectivityforLSD1overMAO-AandMAO-B(IC50valuesare0.51and2.79μMforMAO-AandMAO-B,respectively).Impairslong-term,butnotshort-termmemoryinmice.BrainpenetrantfollowingsystemicadmiNISTration.
RN1dihydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 452.42 |
| Formula | C23H29N3O2.2HCl |
| Storage | Storeat-20°C |
| Purity | ≥97%(HPLC) |
| CASNumber | 1781835-13-9 |
| PubChemID | 90488995 |
| InChIKey | WMHAFZOOUBPQRX-VSIGASKDSA-N |
| Smiles | O=C(N4CCN(C)CC4)CN[C@@H]1C[C@H]1[C@]2=CC=C(OCC3=CC=CC=C3)C=C2.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.05 | 20mMwithgentlewarming | |
| water | 9.05 | 20 |
Thefollowingdataisbasedontheproductmolecularweight452.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.21mL | 11.05mL | 22.1mL |
| 5mM | 0.44mL | 2.21mL | 4.42mL |
| 10mM | 0.22mL | 1.11mL | 2.21mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |



