Antitumoragent.Inhibitstumorcellgrowthinamutantp53-andp73-dependentmannerinvitroandinvivo(IC50=4μM).Transcriptionallyactivatesexpressionofp53-responsivegenesandinducesactivationofeffectorcaspases3and7.
| M.Wt | 305.8 |
| Formula | C11N11NO3S2.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 1173023-52-3 |
| PubChemID | 46861546 |
| InChIKey | ZZAVDVMJZKDBIB-UHFFFAOYSA-N |
| Smiles | OC1=CC(C(CSC2=NCCS2)=O)=CC=C1O.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 30.58 | 100 |
Thefollowingdataisbasedontheproductmolecularweight305.8.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.27mL | 16.35mL | 32.7mL |
| 5mM | 0.65mL | 3.27mL | 6.54mL |
| 10mM | 0.33mL | 1.64mL | 3.27mL |
| 50mM | 0.07mL | 0.33mL | 0.65mL |



