RalAandRalBGTPaseinhibitor(EC50~3.5μM).InhibitsthebindingofRaltoRaLBP1.ExhibitsnodetectableinhibitionofRasorRhoAactivity.Suppressesgrowthofxenografttumorsinmice.Cellpermeable.
RBC8isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 424.45 |
Formula | C25H20N4O3 |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 361185-42-4 |
PubChemID | 6626226 |
InChIKey | CLMQBVUFKIKYLU-UHFFFAOYSA-N |
Smiles | NC1=C(C#N)C(C5=C(OC)C=CC(OC)=C5)C(C(C3=CC=C(C=CC=C4)C4=C3)=NN2)=C2O1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 42.44 | 100 |
Thefollowingdataisbasedontheproductmolecularweight424.45.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.36mL | 11.78mL | 23.56mL |
5mM | 0.47mL | 2.36mL | 4.71mL |
10mM | 0.24mL | 1.18mL | 2.36mL |
50mM | 0.05mL | 0.24mL | 0.47mL |